CLCA1 is Poorly Expressed in Stomach Adenocarcinoma and Correlates with Immune Infiltration / CLCA1 se Expresa Deficientemente en el Adenocarcinoma de Estómago y se Correlaciona con la Infiltración Inmune

SUMMARY: Calcium-activated chloride channel regulator 1 (CLCA1) is associated with cancer progression. The expression and immunologic function of CLCA1 in stomach adenocarcinoma (STAD) remain unclear. In this investigation, the expression of CLCA1 in STAD tissues and its involvement in the progression and immune response of STAD were examined using databases such as cBioPortal, TISIDB, and UALCAN. In order to validate the expression level of CLCA1 protein in gastric adenocarcinoma, thirty clinical tissue specimens were gathered for immunohistochemical staining. The findings indicated a downregulation of CLCA1 in STAD patients, which was correlated with race, age, cancer grade, Helicobacter pylori infection, and molecular subtype. Through the examination of survival analysis, it was identified that diminished levels of CLCA1 within gastric cancer cases were linked to decreased periods of post-progression survival (PPS), overall survival (OS), and first progression (FP) (P<0.05). The CLCA1 mutation rate was lower in STAD, but the survival rate was higher in the variant group. The correlation between the expression level of CLCA1 and the levels of immune infiltrating cells in STAD, as well as the immune activating molecules, immunosuppressive molecules, MHC molecules, chemokines, and their receptor molecules, was observed. Gene enrichment analysis revealed that CLCA1 may be involved in STAD progression through systemic lupus erythematosus (SLE), proteasome, cell cycle, pancreatic secretion, and PPAR signaling pathways. In summary, CLCA1 is anticipated to function as a prognostic marker for patients with STAD and is linked to the immunization of STAD.

El regulador 1 del canal de cloruro activado por calcio (CLCA1) está asociado con la progresión del cáncer. La expresión y la función inmunológica de CLCA1 en el adenocarcinoma de estómago (STAD) aún no están claras. En esta investigación, se examinó la expresión de CLCA1 en tejidos STAD y su participación en la progresión y respuesta inmune de STAD utilizando bases de datos como cBioPortal, TISIDB y UALCAN. Para validar el nivel de expresión de la proteína CLCA1 en el adenocarcinoma gástrico, se recolectaron treinta muestras de tejido clínico para tinción inmunohistoquímica. Los hallazgos indicaron una regulación negativa de CLCA1 en pacientes con STAD, que se correlacionó con la raza, la edad, el grado del cáncer, la infección por Helicobacter pylori y el subtipo molecular. Mediante el examen del análisis de supervivencia, se identificó que los niveles reducidos de CLCA1 en los casos de cáncer gástrico estaban relacionados con períodos reducidos de supervivencia posterior a la progresión (PPS), supervivencia general (OS) y primera progresión (FP) (P <0,05). La tasa de mutación CLCA1 fue menor en STAD, pero la tasa de supervivencia fue mayor en el grupo variante. Se observó la correlación entre el nivel de expresión de CLCA1 y los niveles de células inmunes infiltrantes en STAD, así como las moléculas activadoras inmunes, moléculas inmunosupresoras, moléculas MHC, quimiocinas y sus moléculas receptoras. El análisis de enriquecimiento genético reveló que CLCA1 puede estar involucrado en la progresión de STAD a través del lupus eritematoso sistémico (LES), el proteasoma, el ciclo celular, la secreción pancreática y las vías de señalización de PPAR. En resumen, se prevé que CLCA1 funcione como un marcador de pronóstico para pacientes con STAD y está vinculado a la inmunización de STAD.

Possibilidades de integração entre a fonoaudiologia e a nutrição com base em produções nacionais / Possibilities of integration between speech therapy and nutrition based on national productions / Posibilidades de integración entre la terapia del lenguaje y la nutrición a partir de las producciones nacionales

Introdução: A atuação interdisciplinar entre a fonoaudiologia e a nutrição colabora para um atendimento mais integral entre os usuários da saúde, fato que demonstra a importância de pesquisar suas correlações. Objetivo: O objetivo deste estudo foi verificar se existe integração entre a atuação do fonoaudiólogo e do nutricionista, identificando as publicações existentes, as especialidades contempladas, bem como a atuação dos profissionais nos diferentes ciclos de vida e níveis de atenção à saúde. Metodologia: Foram analisados 3.551 artigos eletrônicos disponíveis eletronicamente dos periódicos CODAS, CEFAC, Distúrbios da Comunicação e Audiology Communication Research, entre os anos de 2013 e 2022, por meio de um Protocolo de Classificação de Artigos. Resultados: Dentre as publicações analisadas, 274 (7,7%) integram a Fonoaudiologia e a Nutrição, especialmente na Especialidade da Motricidade Orofacial (n=124; 26,9%), no Ciclo Vital Infantil (n=132; 43%) e no Nível de Atenção Secundário (n=97; 35,4%). Conclusão: Concluiu-se que existe interface entre as duas profissões, porém, ainda é necessário fortalecer a atuação nos diferentes ciclos de vida. Além disso, incentivar a prática profissional em outros níveis de atenção, especialmente na primária, para prevenção dos distúrbios alimentares e promoção da alimentação saudável entre usuários do sistema de saúde.

Introduction: Interdisciplinary performance between speech therapy and nutrition contributes to a more integral care among health users, a fact that demonstrates the importance of researching their correlations. Objective: The purpose of this study was to verify if there is integration between the performance of the speech therapist and nutritionist, identifying the existing publications, the specialities contemplated, as well the performance of professionals in different life cycles and levels of health care. Methods: 3.551 electronic articles were analyzed, in the electronic journals CODAS, CEFAC, Distúrbios da Comunicação and Audiology Communication Research, between the years 2013 and 2022, through an Article Classification Protocol. Results: Among the analyzed publications, 274 (7,7%) integrate Speech Language and Hearing Sciences and Nutrition, especially in orofacial motricity (n=124; 26,9%), Children's Life Cycle (n=132; 43%), and secondary care level (n=97; 35,4%). Conclusion: it was concluded that there is an interface between the two professions, although it is still necessary to strengthen the performance in the different life cycles. Furthermore, to encourage professional practice at other levels of care, especially in the primary, to prevent nourishment disorders and promote healthy eating among users of the health system

Introducción: El rendimiento interdisciplinario entre la terapia del habla y la nutrición contribuye a una atención más integral entre los usuarios de la salud, un hecho que demuestra la importancia de investigar sus correlaciones. Objetivo: El objetivo de este estudio fue verificar si existe integración entre la terapia del habla y la nutricionista, identificando las publicaciones existentes, las especialidades contempladas, así como la actuación de los profesionales en diferentes ciclos de vida y niveles de atención a la salud. Métodos: Fueron analizados 3.551 artículos electrónicos, en las revistas electrónicas CODAS, CEFAC, Distúrbios da Comunicação y Audiology Communication Research, entre los años 2013 a 2022, a través de un Protocolo de Clasificación de Artículos. Resultados: Entre las publicaciones analizadas, 274 (7,7%) integran terapia del habla y Nutrición, especialmente en motricidad orofacial (n=124; 26,9%), Ciclo de Vida Infantil (n=132; 43%), y secundaria nivel asistencial (n=97; 35,4%). Conclusións: Se concluyó que existe una interfaz entre las dos profesiones, aunque aún es necesario fortalecer el desempeño en los diferentes ciclos de vida. Además, incentivar la práctica profesional en otros niveles de atención, especialmente en el primario, para prevenir trastornos de la alimentación y promover la alimentación saludable entre los usuarios del sistema de salud.

Ciclos de vida: análise das publicações na revista Distúrbios da Comunicação no período de 2016 a 2020 / Life cycles: analysis of publications in Communication Disorders Journal from 2016 to 2020 / Ciclos de vida: análisis de las publicaciones en la revista Disturbios de la Comunicación de 2016 a 2020

Introdução: ciclo de vida é atualmente considerado elemento essencial à formulação e implantação de políticas públicas pautadas no cuidado integral à saúde. Objetivo: analisar a produção científica da Revista Distúrbios da Comunicação no período de 2016 a 2020, tendo como objeto de discussão as publicações da área da Fonoaudiologia por ciclos de vida. Método: estudo retrospectivo, de abordagem metodológica bibliométrica, analisou 297 artigos considerando as seguintes variáveis: ano de publicação, registro da região geográfica (do primeiro autor), descritores, áreas temáticas, tipo de estudo e tamanho da amostra, segundo faixas etárias (0-6; 7-11; 12-18;19-59 e >60). A análise dos dados foi descritiva, numérica e percentual. Resultados: dos 297, estudos, 258 fizeram referência a uma ou mais faixas etárias e 39 não mencionaram qualquer idade. Dentre os 258, os estudos mais frequentes foram de criança (138; 46,2%), seguido pelos de adultos (122; 41,1%). A amostra variou quanto à mediana entre 27 (adulto) a 38 (crianças: 0-6 anos) sujeitos. A região Sudeste registrou maior número de artigos relacionados a todos os ciclos, assim como os estudos do tipo observacional, com destaque para os realizados com adultos (98; 33,9%). Pouca menção foi feita a descritores que identificam os ciclos de vida (75; 6%), sendo idoso (25; 38%) e criança (23; 35%) os mais registrados. Conclusão: os dados evidenciam a premência de alinhamento das pesquisas às políticas públicas de saúde, bem como ressalta a importância do uso de descritores adequados para maior circulação do conhecimento produzido pela área. (AU)

Introduction: life cycle is currently considered an essential element for the formulation and implementation of public policies based on comprehensive health care. Objective: to analyze the scientific production of Communication Disorders Journal from 2016 to 2020, having as an object of discussion publications in the field of Speech Therapy by life cycles. Method: a retrospective study, with a bibliometric methodological approach, analyzed 297 articles considering the following variables: year of publication, registration of the geographic region (of the first author), descriptors, thematic areas, type of study and sample size, according to age groups (0 -6; 7-11; 12-18; 19-59 and >60). Data analysis was descriptive, numerical and percentage. Results: of the 297 studies, 258 referred to one or more age groups and 39 did not mention any age. Among the 258, the most frequent studies were children (138; 46.2%), followed by adults (122; 41.1%). The sample ranged in terms of median from 27 (adult) to 38 (children: 0-6 years) subjects. The Southeast region recorded the highest number of articles related to all cycles, as well as observational studies, especially those carried out with adults (98; 33.9%). Little mention was made of descriptors that identify life cycles (75; 6%), being elderly (25; 38%) and children (23; 35%) the most registered. Conclusion: the data show the urgency of aligning research with public health policies, as well as highlighting the importance of using appropriate descriptors for greater circulation of knowledge produced by the area. (AU)

Introducción: el ciclo de vida es considerado en la actualidad un elemento esencial para la formulación e implementación de políticas públicas basadas en la atención integral de la salud. Objetivo: analizar la producción científica de la Disturbios de la Comunicación de 2016 a 2020, teniendo como objeto de discusión publicaciones en el campo de la Logopedia por ciclos de vida. Método: estudio retrospectivo, con enfoque metodológico bibliométrico, se analizaron 297 artículos considerando las siguientes variables: año de publicación, registro de la región geográfica (del primer autor), descriptores, áreas temáticas, tipo de estudio y tamaño de la muestra, según grupos de edad (0-6; 7-11; 12-18; 19-59 y >60). El análisis de los datos fue descriptivo, numérico y porcentual. Resultados: de los 297 estudios, 258 se refirieron a uno o más grupos de edad y 39 no mencionaron ninguna edad. Entre los 258, los estudios más frecuentes fueron los niños (138; 46,2%), seguidos de los adultos (122; 41,1%). La muestra osciló en términos de mediana de 27 (adultos) a 38 (niños: 0-6 años) sujetos. La región Sudeste registró el mayor número de artículos relacionados con todos los ciclos, además de estudios observacionales, en especial los realizados con adultos (98; 33,9%). Se hizo poca mención de descriptores que identifican ciclos de vida (75; 6%), siendo ancianos (25; 38%) y niños (23; 35%) los más registrados. Conclusión: los datos muestran la urgencia de alinear la investigación con las políticas públicas de salud, además de resaltar la importancia de utilizar descriptores apropiados para una mayor circulación del conocimiento producido por el área. (AU)

Pediatría: un enfoque integral desde sus orígenes hasta la actualidad / Pediatrics: A Comprehensive Approach From its Origins to Present Day / Pediatria: uma abordagem integral desde suas origens até o presente

El término pediatría surge del griego paidos (niño) e iatrea (curación). Inicialmente, la pediatría fue descrita como una de las ramas independientes de la medicina en Europa Central durante la segunda mitad del siglo XIX; se independizó de áreas como la obstetricia y la medicina interna de forma progresiva. Fue descrita por primera vez en 1722 en el tratado Paedojatreja práctica por el profesor de anatomía y teoría médica Theodor Zwinger de la Universidad de Basileam. Los escritos más antiguos de los que se tiene conocimiento de enfermedades en población pediátrica datan de 2100 a. de C., en donde primaba el componente mágico-religioso (1). En Colombia, sus primeros reportes inician en 1868 con el inicio de la época denominada «Segunda etapa de la medicina colombiana¼, tras la fundación de la Universidad de los Estados Unidos de Colombia en Bogotá, en donde se implementa la cátedra de obstetricia y patología especial de las mujeres y niños, por el médico y presidente Santos Acosta. Posteriormente, se separan las asignaturas de obstetricia y patología especial de las mujeres, originándose la cátedra opcional de patología e higiene de la infancia. En 1891, José Ignacio Barberi, bogotano graduado de la Universidad Nacional de Colombia en el año 1881, se convierte en el primer especialista en dictar la asignatura Clínica infantil. En 1911, con la cátedra de pediatría en la Universidad de Antioquia, nace la especialidad en ese departamento, y el 27 de julio de 1917 se funda la Sociedad Colombiana de Pediatría, la cual propende por el bienestar de los niños y adolescentes, su familia y la sociedad, para el desarrollo de la pediatría como disciplina del hombre (2,3).

The term pediatrics comes from the Greek paidos (child) and iatrike (medicine). Initially, pediatrics was described as one of the independent branches of medicine in Central Europe during the second half of the 19th century. It progressively became independent from areas such as obstetrics and internal medicine. It was first described in 1722 in the treatise Paedojatreja práctica by the professor of anatomy and medical theory Theodor Zwinger of the University of Basel. The oldest known works on diseases in the pediatric population date back to 2100 B.C., in which the magical-religious component was predominant (1). In Colombia, its first reports begin in 1868 with the start of the period called the "Second stage of Colombian medicine". After the foundation of the Universidad de los Estados Unidos de Colombia in Bogotá. The subject of obstetrics and special pathology of women and children was implemented by physician and President Santos Acosta. Subsequently, the subjects of obstetrics and special pathology of women were separated, creating the optional subject of childhood pathology and hygiene. In 1891, José Ignacio Barberi, a Bogotá native graduated from the Universidad Nacional de Colombia in 1881, became the first specialist to teach the subject Children's medicine. In 1911, the specialization was born in the department of Antioquia with the subject of pediatrics at University of Antioquia. The Colombian Society of Pediatrics was founded on July 27, 1917, which advocates for the well-being of children and adolescents, their families and society, to develop pediatrics as a human discipline (2,3).

O termo pediatria vem do grego paidos (criança) e iatrea (cura). Inicialmente, a pediatria foi descrita como um dos ramos independentes da medicina na Europa Central durante a segunda metade do século XIX; tornou-se progressivamente independente de áreas como obstetrícia e medicina interna. Foi descrita pela primeira vez em 1722 no tratado Paedojatreja prática de Theodor Zwinger, professor de anatomia e teoria médica na Universidade de Basileam. Os escritos mais antigos de que se tem conhecimento sobre doenças na população pediátrica datam de 2100 a.C., o componente mágico-religioso era predominante (1). Na Colômbia, seus primeiros relatos começam em 1868 com o início da era denominada «Segunda etapa da medicina colombiana¼, após a fundação da Universidade dos Estados Unidos da Colômbia em Bogotá, onde foi implantada a cátedra de obstetrícia e patologia especial de mulheres e crianças, pelo médico e presidente Santos Acosta. Posteriormente, separam-se as disciplinas de obstetrícia e patologia especial de mulheres, dando origem à cadeira facultativa de patologia e higiene infantil. Em 1891, José Ignacio Barberi, natural de Bogotá, formado pela Universidade Nacional da Colômbia em 1881, tornou-se o primeiro especialista a lecionar a disciplina de Clínica Infantil. Em 1911, com a cátedra de pediatria da Universidade de Antioquia, nasceu a especialidade nesse departamento e, em 27 de julho de 1917, foi fundada a Sociedade Colombiana de Pediatria, que visa o bem-estar de crianças e adolescentes, suas famílias e a sociedade, para o desenvolvimento da pediatria como disciplina humana (2,3).

A redução de risco de desastres, a agenda dos Objetivos Sustentáveis e os princípios do SUS, no contexto da pandemia de COVID-19 / Disaster risk reduction, the Sustainable Goals agenda and the principles of the SUS, in the context of the COVID-19 pandemic

Resumo O objetivo foi analisar os nexos entre o Marco de Sendai para a Redução do Risco de Desastres, os Objetivos de Desenvolvimento Sustentável (ODS) e os princípios do Sistema Único de Saúde (SUS), no contexto da emergência de saúde pública da pandemia de COVID-19, e suas potenciais implicações para a saúde da população. O estudo é qualitativo, transversal, exploratório, com dados coletados junto a profissionais de saúde com experiência em práticas assistenciais e de gestão de risco de emergências e desastres, e tratados pelo software Iramuteq para análise lexical. O corpus textual foi apresentado através da classificação hierárquica descendente, que originou sete classes aglutinadas em três categorias denominadas: resposta a desastres no contexto do SUS; prevenção de futuros riscos de desastres; e ações de preparação e recuperação a partir do Marco de Sendai e dos ODS. Ressaltou-se aspectos sobre os efeitos diretos e indiretos da pandemia de COVID-19 e os desafios relacionados à redução do risco de desastres preconizados no Marco de Sendai, apontando a necessidade de fortalecer a cultura de segurança e sustentabilidade no âmbito do SUS, o que se coaduna com os ODS, bem como aos determinantes sociais da saúde.

Abstract The aim of this study was to analyze the connections between the Sendai Framework for Disaster Risk Reduction, the Sustainable Development Goals (SDGs), and the principles of Brazil's Unified Health System (SUS) in the context of the public health emergency caused by the COVID-19 pandemic and its potential implications for population health. This qualitative, cross-sectional, exploratory study collected data from health professionals with experience in emergency and disaster risk management and treatment practices, which were then processed using the Iramuteq software for lexical analysis. The textual corpus was presented through a descending hierarchical classification that resulted in seven classes grouped into three categories: disaster response in the context of SUS; prevention of future disaster risks; and preparedness and recovery actions based on the Sendai Framework and the SDGs. The study highlighted aspects related to the direct and indirect effects of the COVID-19 pandemic and the challenges related to disaster risk reduction as advocated by the Sendai Framework, emphasizing the need to strengthen the culture of safety and sustainability within the SUS, which aligns with the ODS and social determinants of health.

Differences of temporomandibular joint symmetry in patients with unilateral complete cleft lip and palate at different developmental stages / 中南大学学报(医学版)

OBJECTIVES@#Currently, the research results regarding the bilateral temporomandibular joint symmetry in patients at different ages with unilateral complete cleft lip and palate (UCLP) are still controversial. In this study, the position of condyle in the articular fossa and morphology of condyle in UCLP patients at different developmental stages was measured and analyzed to explore the asymmetry difference, which can provide a new theoretical basis for the sequential therapy.@*METHODS@#A total of 90 patients with UCLP were divided into a mixed dentition group (31 cases), a young permanent dentition group (31 cases) and an old permanent dentition group (28 cases) according to age and dentition development. Cone beam computed tomography (CBCT) images were imported into Invivo5 software for 3D reconstruction, and the joint space, anteroposterior diameter, medio-lateral diameter, and height of condylar were measured, and its asymmetry index was calculated.@*RESULTS@#The asymmetry index of condylar height and anteroposterior diameter among the 3 groups, from small to large, was the mixed dentition group<the young permanent dentition group<the old permanent dentition group (both P<0.05). There was no significant difference in condylar anteroposterior diameter and asymmetry index between the mixed dentition group and the young permanent dentition group (both P>0.05), all of them were lower than those in the old permanent dentition group (both P<0.05). Compared with the normal side, the height of fracture condyle was smaller among the 3 groups (all P<0.05), and the anterior joint space was smaller (P<0.05) and the posterior joint space was larger (P<0.05) in the mixed dentition group.@*CONCLUSIONS@#In patients with UCLP, the asymmetry of condylar morphology increases with age, but the condylar position tends to normal. These results suggest that early treatment has important clinical significance for the morphologic development of temporomandibular joint in UCLP patients.

Previsões do número de cirurgias suspensas utilizando o software Power BI® em um hospital universitário / Predictions of the number of suspended surgeries using software Power BI® in a university hospital / Predicciones del número de cirugías suspendidas utilizando software Power BI® en un hospital universitario

Objetivo: analisar as cirurgias suspensas, realizando previsões futuras de três meses, a partir de outubro de 2022, através de um gráfico de linhas utilizando o software Power BI®. Método: se utilizou a técnica de médias moveis ponderada, alisamento exponencial simples, utilizando a ferramenta gráfico de linhas do Power BI®, com intervalo de confiança de 95% e previsões de três meses. Resultados: os resultados demostraram que existem diferentes etapas para construir previsões e alguns pré-requisitos devem ser preenchidos, foram encontradas as seguintes previsões com seus respectivos intervalos de confiança novembro 134(97,172), dezembro 141(102,180), janeiro 147(106.188). Conclusão: a utilização de previsões pode ser uma ferramenta útil para a tomada de decisão, prever problemas e sempre necessário na gestão de um hospital, podendo até suprimir gastos se antecipando a uma variedade de problemas.

Objective: to analyze the suspended surgeries, making future predictions of three months, starting in October 2022, through a line graph using the Power BI software. Method: we used the technique of weighted moving averages, simple exponential smoothing, using the Power BI® line graph tool, with a confidence interval of 95% and predictions of three months. Results: the results showed that there are different steps to construct predictions and some prerequisites must be fulfilled, the following predictions were found with their respective confidence intervals: November 134 (97,172), December 141 (102,180), January 147 (106,188). Conclusion: the use of forecasts can be a useful tool for decision making, predicting problems and always necessary in the management of a hospital, and can even suppress expenses in anticipation of a variety of problems.

Objetivos:analizar las cirugías suspendidas, haciendo predicciones futuras de tres meses, a partir de octubre de 2022, a través de un gráfico lineal utilizando el software Power BI®. Método: se utilizó la técnica de medias móviles ponderadas, suavizado exponencial simple, utilizando la herramienta de gráfico de líneas de Power BI®, con un intervalo de confianza del 95% y predicciones de tres meses. Resultados: los resultados mostraron que existen diferentes pasos para construir predicciones y se deben cumplir algunos requisitos previos, se encontraron las siguientes predicciones con sus respectivos intervalos de confianza: noviembre 134 (97,172), diciembre 141 (102,180), enero 147 (106,188). Conclusión: el uso de pronósticos puede ser una herramienta útil para la toma de decisiones, predicción de problemas y siempre necesaria en la gestión de un hospital, e incluso puede suprimir gastos en previsión de una variedad de problemas.

Life cycle phases: Literature review and new classification proposal for application in healthcare

ABSTRACT Introduction: Although uncommon in dentistry, the concept of the life cycle holds great importance for dental professionals in identifying crucial intervention opportunities and determining the optimal timing for treatments and procedures. Objective: To carry out a review of the literature on life cycle classifications and their distinct phases, evaluating their applicability in healthcare. Methods: A literature review was performed, searching for articles in PubMed, SciELO, National Health Library (BvB), and Google Scholar databases, as well as relevant books. The keywords "life cycle," "life stages," "human development," "age groups," and "biological age" were used. Relevant articles were selected by analyzing their titles and abstracts, and read in full to confirm their inclusion in the research. Results: Nine distinct life cycle classifications were found, each with unique criteria. Conclusion: Based on the comprehensive literature review, a novel classification was proposed (The 10-phase Life Cycle), which encompasses dental, growth, physiological aging, sociocultural, and behavioral characteristics, aiming to enhance communication among healthcare professionals, particularly those engaged in the growth, development, and aging processes of human beings.

RESUMO Introdução: Embora incomum na Odontologia, o conceito de ciclo vital é de grande importância para ajudar os profissionais dessa área a identificar oportunidades cruciais para intervenções e para determinar o momento ideal para tratamentos e procedimentos. Objetivo: Realizar uma revisão da literatura sobre as classificações do ciclo vital e suas distintas fases, avaliando sua aplicabilidade na área da saúde. Métodos: Foi realizada uma revisão da literatura, buscando artigos nas bases de dados PubMed, SciELO, Biblioteca Nacional de Saúde (BvB) e Google Acadêmico; além de livros relevantes. Foram utilizadas as palavras-chave "ciclo vital", "estágios de vida", "desenvolvimento humano", "faixas etárias" e "idade biológica". Os artigos relevantes foram selecionados por meio da análise de seus títulos e resumos e lidos na íntegra para confirmar sua inclusão na pesquisa. Resultados: Nove classificações distintas de ciclo vital foram encontradas, cada uma com critérios únicos. Conclusão: Com base nessa revisão abrangente da literatura, é proposta uma nova classificação (o ciclo vital de 10 fases) que engloba características dentárias, de crescimento, envelhecimento fisiológico, socioculturais e comportamentais, com o objetivo de melhorar a comunicação entre os profissionais da área de saúde, particularmente aqueles envolvidos nos processos de crescimento, desenvolvimento e envelhecimento do ser humano.

Cognitive Reserve in Older Adults: A Cluster Analysis / Reserva Cognitiva em Adultos Idosos: Uma Análise de Cluster

Abstract Cognitive reserve (CR) is a construct generally associated with neurodegenerative diseases in aging. The aim of this paper was to examine the CR profiles of older adults at different stages of their lifespan and evaluate the importance of: (a) gender and CR; and (b) CR, cognition, and symptoms of depression. A sample of 195 older adults volunteered to participate in the study, and a cluster analysis was carried out on their responses in terms of the Cognitive Reserve Scale. The cluster analysis depicted two different profiles. Furthermore, women had a better CR than men. The results provide an important contribution to understanding the variables related to the CR construct.

Resumo A reserva cognitiva (RC) é um construto geralmente associado a doenças neurodegenerativas no envelhecimento. O objetivo deste estudo foi examinar os perfis de RC em adultos idosos em diferentes estágios da vida, e avaliar o efeito de: (a) gênero e RC; e (b) RC, cognição e sintomas depressivos. A amostra contou com 195 adultos, e uma análise de cluster foi realizada a partir dos escores obtidos na Escala de Reserva Cognitiva. A análise de cluster descreveu dois perfis diferentes. Além disso, as mulheres apresentaram maior RC em comparação aos homens. Os resultados fornecem contribuições importantes para as variáveis relacionadas ao construto da RC.

Correlation between early life exposure to PM 2.5 and risk of autism spectrum disorder among school aged children / 中国学校卫生

Objective@#To investigate the associations between early life exposure to particulate matter with an aerodynamic diameter less than 2.5 μm (PM 2.5 ) and the risk of autism spectrum disorder (ASD) among school aged children.@*Methods@#A total of 165 children with ASD and 165 age and gender matched typical development (TD) children were recruited. Children s basic information were obtained via questionnaires, and the severity of ASD symptoms was assessed with Social Responsiveness Scale (SRS). Early life PM 2.5 exposure (preconception, entire pregnancy, and the first two years after birth) were extracted from the Tracking Air Pollution in China (TAP) datasets. Conditional Logistic regression and generalized linear model were used to evaluate the associations of early life exposure to PM 2.5 with the risk and the ASD severity symptoms, respectively.@*Results@#The PM 2.5 exposure of ASD group during preconception[(55.08±9.34)μg/m 3], entire pregnancy[(50.44±8.71)μg/m 3], the first year after birth [(45.04± 8.25 )μg/m 3] and the second year after birth [(40.19±7.12)μg/m 3] were significant higher than those in TD children [(47.66± 7.63 , 44.19±7.16, 38.95±6.07, 35.76±5.65)μg/m 3]( t =7.94, 7.13, 7.70, 6.32, P <0.05). After adjusting for potential confounding, each increase of 1 μg/m 3 in PM 2.5 was associated with higher risk of ASD during preconception ( OR=1.21, 95%CI =1.13-1.29), entire pregnancy( OR=1.18, 95%CI =1.11-1.26), the first year after birth ( OR=1.30, 95%CI =1.18-1.43) and the second year after birth ( OR=1.29, 95%CI =1.17-1.42). No similar results were observed regarding the analyses of SRS total and sub scale scores( P >0.05).@*Conclusion@#Early life exposure to PM 2.5 is relate to the risk of ASD, these findings indicated that more attention should be paid to ambient PM pollution in the early life prevention and control of ASD.

Effects of a Workplace mHealth Intervention for Smoking Behaviour: A Quasi Experimental Study Protocol

@#Introduction: Tobacco smoking causes various chronic diseases and adds costs to healthcare systems. The current smoking cessation interventions mostly target smokers who are ready to quit and are reactive in recruitment. Recently, mobile phones have become a new tool for promoting smoking cessation. The aim of this paper is to present a study protocol on a quasi-experimental study investigating the effects of a workplace mHealth intervention for smoking behaviour. Methods: A quasi-experimental study will be conducted among employees in an academic institution in Malaysia. The intervention group will receive a theory based WhaSTOP module via WhatsApp and will be compared with the control group (receive usual care). The primary outcomes are stage movement and the number of cigarettes per day. The secondary outcomes include knowledge of smoking, quit attempt, nicotine dependence, 7-day point prevalence of smoking abstinence, and the Transtheoretical Model constructs. A generalised estimating equation analysis will be performed to determine the effects of the intervention. Discussion: This protocol will provide a novel method to proactively approach smokers regardless of readiness to quit and to guide them through the stages of change so that they will be ready to take action to quit. This research will also provide insight into whether the intervention can be utilised as an additional tool for smokers at the workplace to quit smoking. Trial Registration: The trial was registered with the Iranian Registry of Clinical Trials (Registry Number IRCT20220415054539N1).

Effect of parental weight and early life factors on overweight and obesity in children and adolescents / 中国学校卫生

Objective@#To investigate the association of the risk of overweight/obesity in children and adolescents with their early life factors and parental weight.@*Methods@#From June 1 to June 30 of 2022, the stratified randomized cluster sampling method was used to collect information using questionnaires from 5 370 primary and secondary school students in Hohhot City, Inner Mongolia Autonomous Region, and multivariate analysis were performed using multiple Logistic regression model estimation in a generalized linear model for parental BMI and early life factors in children and adolescents.@*Results@#The prevalence of overweight/obesity was 32.2% , and the prevalence of overweight/obesity among male students was 37.8%, which was higher than that of female students 26.1% χ 2= 84.59 , P <0.01). The results of the multirariate Logistic regression anaysis showed that the prevalence of overweight/obesity was higher in only paternal overweight ( OR=1.52, 95%CI =1.30-1.77), only maternal overweight ( OR=1.61, 95%CI = 1.31 -1.97), and parentl overweight ( OR=2.42, 95%CI =2.03-2.87)( P <0.05). The risk of overweight/obesity was higher in children with high birth weight ( OR=1.29, 95%CI =1.08- 1.55 ), children born by caesarean section ( OR=1.32, 95%CI =1.17- 1.48 ), and children whose mothers gained excessive weight during pregnancy ( OR=1.24, 95%CI =1.06-1.46), and the results were statistically significant ( P <0.05).@*Conclusions@#Overweight parents, excessive maternal weight gain during pregnancy, cesarean delivery, and high birth weight are associated with increased risk of overweight/obesity in children and adolescents. Attention should be paid to these aspects in obesity prevention and control.

Association between early life factors and cardiometabolic risk factors in children and adolescents / 中国学校卫生

Objective@#To understand the early life factors that influence cardiometabolic risk factors in children and adolescents, so as to provide effective measures to curb cardiometabolic risk factors such as hypertension and diabetes in children and adolescents.@*Methods@#Data were sourced from the 2020 follow up survey of the Xiamen Adolescent Development Cohort. The study involved 1 197 subjects for whom completed anthropometric examination and blood biochemistry testing data, as well as early life data. Early life and sociodemographic data were obtained through questionnaire surveys, while cardiometabolic indicator data were sourced through physical examinations and blood testing. Logistic regression analysis was performed to analyze the impact of early life factors on the cardiometabolic risk factors after adjusting for gender, age, and family history.@*Results@#The prevalence rate of cardiometabolic risk factors clustering in children and adolescents in Xiamen was 17.96%, with boys (26.67%) reporting higher rates than girls (9.64%), and the difference was statistically significant ( χ 2=57.69, P <0.01). For every additional early life risk factor, the risk factors of obesity increased 0.35 times ( OR=1.35, 95%CI=1.03-1.78, P <0.05). Post term pregnancy may be a primary early life risk factors for cardiometabolic risk factors, and it was associated with an increased risk of cardiometabolic risk factors clustering (OR=2.45, 95% CI =1.11-5.41) and high triglycerides ( OR=3.25, 95%CI =1.39-7.61)( P <0.05).@*Conclusion@#Increased cardiometabolic risk factors in youth is associated with early life adverse factors. It is crucial to pay greater attention to post term pregnancy as an early life factor and to consider obesity as a cardiometabolic risk factors. Controlling early life adverse factors is important for the prevention of cardiovascular disease.

Sexual Maturity Scale of the Swimming Crab Callinectes pallidus (Rochebrune, 1883) from Lake Nokou� in South Benin, West Africa

Aims: Reproductive parameters are important tools for the sustainable management of halieutic species in the water bodies of its exploitation. This study intends to characterize the sexual maturity scale of swimming crab Callinectes pallidus, perform testicular and ovarian structures in order to develop a specific maturity scale. Study Design: This study was carried out with macroscopic and microscopic observations of 394 specimens of crabs including 206 females and 188 males. Place and Duration of Study: The specimens used in this study were collected monthly from March to July 2018 from small scale fisheries of Lake Nokou� (Benin). Methodology: At the laboratory, each crab specimen is identified and its sex determined. Grids for describing each sexual maturity stage of the crab C. pallidus were developed based on the Zairon et al. (2015) scale. Histological sections of female and male gonads were analyzed in order to certify the different stages of sexual development noted from the macroscopic study. Results: Macroscopic analysis of external and internal anatomy and histological study of male and female gonads of C. pallidus allowed to establish a sexual maturity scale with 5 stages in females and 4 stages in males respectively. Macroscopic observations made with a binocular magnifying glass allowed to describe the characteristic features of the sexual development cycle of the species. The histological study confirmed the results of the macroscopic analysis. Significant difference was recorded between the mean oocytes diameters of the different oocyte development stages (p<0.05). Conclusion: The outcomes of this constitute an important database for the assessment of the reproductive parameters of the species in the water bodies of its exploitation. The stages IV and V are the mature steps in the female development whereas the stages III and IV are that of the male. It is recommended to allow C. pallidus reach the sexual maturity size (5,95 cm for female and 6,38 cm for male) before their exploitation to ensure the sustainable management of the species.

Estimation of Time Since Death of Bodies Above Soil Surface in A Guinea Forest-Savannah Vegetation of Nigeria Using Visible Post Mortem Changes

Background: Forensic taphonomy is the use of decomposition timeline estimation to unravel mystery behind time of death confirmation in homicide cases involving the law court. The Guinea forest-savannah vegetation is one of the vegetations in Nigeria characterized by short trees, grassland, very hot temperatures almost round the year, speedy wind, etc. It has two distinct seasons – rainy and dry seasons. This study aimed at investigating the visible post mortem changes of domestic pigs (Sus scrofa domestica) in a Guinea forest-savannah vegetation of Nigeria so that it can be used to estimate time since death of bodies on the soil surface. Methods: A stratified random sampling technique was used to select two male and two female matured domestic pigs from a private pig farm located close to the research facility. The visible post mortem changes were observed daily (morning, afternoon and evening) for 49 days. Results: Four stages of decomposition were identified namely fresh, bloat, active decay, and advanced decay stages. Mummification process started at the sixth day post mortem which slowed the rate of decomposition, and prevented the animals to completely skeletonize within the study period. Extreme atmospheric temperature was the major factor that aided the mummification of the animals. Conclusions: Decomposition of domestic pigs in this region accelerates at the early hours of post mortem, and subsequently slows down due to extreme climatic conditions. In addition, it takes carcasses on the soil surface more than 49 days to completely skeletonize due to its vegetative factors. This implies that most crime investigations carried out in this region must take into account the climatic conditions before estimating the time of death.

Cunoniaceae, nuevo registro de familia de plantas hospederas para los géneros altoandinos Penaincisalia y Micandra (Lycaenidae: Theclinae: Eumaeini) / Cunoniaceae, new family food plant record for the high altitude Andean genera Penaincisalia and Micandra (Lycaenidae: Theclinae: Eumaeini)

Resumen Orugas de dos especies altoandinas de Eumaeini (Lycaenidae: Theclinae) fueron halladas consumiendo hojas de Weinmannia crassifolia Ruiz & Pav., 1802 (Cunoniaceae). La colecta se realizó usando la técnica de colecta por golpeo. Esta familia de plantas es registrada por primera vez como planta alimenticia de los Eumaeini. Aunque no pudimos completar la crianza, las especies de Lycaenidae fueron identificadas mediante sus códigos de barra de ADN. Las orugas de Penaincisalia purpurea (K. Johnson, 1992) y Micandra dignota (Draudt, 1919) se describen e ilustran por primera vez. También se presentan datos sobre su ecología y relaciones con especies similares. Una tercera especie, registrada en estadio pupal en la misma planta de W. crassifolia fue un Nymphalidae, Perisama diotima (Hewitson, 1852).

Abstract Caterpillars of two Andean species of Eumaeini (Lycaenidae: Theclinae) were found eating leaves of Weinmannia crassifolia Ruiz & Pav., 1802 (Cunoniaceae). They were collected by "beating" the leaves. This plant family is reported for the first time as a food plant for Eumaeini. Although it was not possible to rear the caterpillars to the adult stage, we identified them using DNA barcodes. The caterpillars of Penaincisalia purpurea (K. Johnson, 1992) and Micandra dignota (Draudt, 1919) are described and illustrated for the first time. Data on their ecology and relationships with similar species are also presented. A third species collected on the same plant of W. crassifolia in the pupal stage was a Nymphalidae, Perisama diotima (Hewitson, 1852).

Cuestionario de clasificación de etapas de cambio y cesación de consumo de cigarrillo/tabaco CCET / Questionnaire for the Classification of the Stages of Change and Cessation of Consumption of Cigarette/Tobacco CCET

Resumen El consumo de cigarrillo ha tenido un gran impacto en la salud, por lo que es urgente y necesario trabajar en la generación de interés en la cesación. El objetivo de la presente investigación fue el diseño y validación del Cuestionario de Clasificación de Etapas de Cambio y Cesación de Consumo de Cigarrillo/Tabaco CCET, que permite la categorización del consumidor de acuerdo con las siete etapas descritas en el modelo teórico Proceso de Adopción de Precauciones que propuso Weinstein en 1988. El CCET consta de 16 ítems que interrogan acerca de las características definidas para cada fase de cambio de la conducta del individuo, consumo y el logro de la cesación. La muestra estuvo conformada por 200 estudiantes de educación superior fumadores (138 hombres y 62 mujeres) entre los 18 y 57 años. Se determinó la validez de contenido a través del juicio de expertos quienes analizaron los criterios de redacción, pertinencia y suficiencia de cada una de las preguntas utilizadas en dicho cuestionario, se realizó la aplicación en su versión definitiva para determinar las características técnicas de acuerdo con el Modelo de Rasch. Del mismo modo que en estudios previos buena parte de la muestra presento ubicación en las primeras etapas, es decir no necesariamente con deseo de dejar de fumar.

Abstract Cigarette consumption has had a great impact on health, so it is urgent and necessary to work on generating interest in cessation. The purpose of the present investigation was the design and validation of the Questionnaire for the Classification of the Stages of Change and Cessation of Consumption of Cigarette/Tobacco, which allows the categorization of the consumers according to the seven stages exposed in the theoretical Precaution Adoption Process Model proposed by Weinstein in 1988. The questionnaire consists of 16 items that ask about the characteristics defined for each stage of individual behavior change, consumption, and achievement of cessation. The sample consisted of 200 smoking students in higher education (138 men and 62 women) between 18 and 57 years of age. The validity of the content was determined through the judgment of experts who analyzed the wording, relevance, and sufficiency of each of the questions used in the questionnaire. The final version of the questionnaire was applied to determine the technical characteristics according to the Rasch Model. As in previous studies, a good part of the sample was located in the early stages, that is, not necessarily with a desire to quit smoking.

Cytogenetic analysis of two species of genus Protosticta from Himachal Pradesh, India

Cytogenetically, out of 262 species, only three species of family Platystictidae has been reported worldwide. Present study has been undertaken to study chromosome complement and its characterization of more species of this family. Cytogenetic analyses of Protosticta sanguinostigma Fraser, 1992 and Protosticta uncata Fraser, 1931 of family Platystictidae, collected from Andretta, Himachal Pradesh, India have been carried out on the basis of conventional staining, C-banding and silver nitrate staining. Both the species possess n=13m as haploid chromosome number and X0-XX sex determining mechanism. One large bivalent is present in all the meiotic stages of P. sanguinostigma which is considered as the species specific character. Chromosome complement of both the species shows variation in distribution of C-bands and Nucleolar organizer regions (NORs). Cytologically, both the species have been described for the first time.

Mammography Stages Adoption and Health Beliefs in Mexican Women / Etapas de Cambio en el Uso de la Mamografía y Creencias de Salud en Mujeres Mexicanas

Abstract Objective. To identify associations between sociodemographic variables and stages of change and evaluate differences between health belief model variables and these stages. Methods. This cross-sectional descriptive study included 612 women aged 40 years and older admitted to a public hospital in the Northeast of Mexico. The participants answered the health belief model scale and selected the statement that best reflected their experience with mammography screening. The association between sociodemographic and clinical variables and the mammography stages of change was assessed using X2, and the groups of stages of change were compared using one-way ANOVA and Games-Howell post-hoc tests. Results. There was a significant association between age and the stages of action and maintenance. Breast cancer screening methods such as breast self-examination and clinical breast examination were more common among women in the stages of maintenance and relapse. There were differences between pre-contemplation and the more advanced stages in all dimensions except in the perceived seriousness p <.001. Self-efficacy and health motivation were different among women at the stage of contemplation, maintenance, and relapse. Conclusions. Perceived self-efficacy and health motivation may increase adherence to mammography screening.

Resumen El objetivo de la investigación fue identificar la asociación entre las variables sociodemográficas y las etapas de cambio para el uso de la mamografía y evaluar si existen diferencias entre las dimensiones del modelo de creencias en salud y las etapas de cambio. El diseño de este estudio es transversal descriptivo, se realizó de enero de 2017 a enero de 2018, incluyó a 612 mujeres de 40 años en adelante que asistían a un hospital de atención terciaria en el noreste de México. Las participantes firmaron el consentimiento informado y respondieron a la escala del modelo de creencias en salud y seleccionaron la declaración que mejor reflejaba su experiencia con la mamografía. La asociación entre las variables sociodemográficas y clínicas y las etapas de cambio de la mamografía se evaluó mediante X2, y los grupos de etapas de cambio se compararon mediante pruebas post hoc de ANOVA unidireccional y Games-Howell. Se encontró una asociación significativa entre la edad y las etapas de cambio de acción y mantenimiento. Los métodos de detección del cáncer de mama, como la autoexploración de mama y el examen clínico de mama, fueron más comunes entre las mujeres en las etapas de mantenimiento y recaída. Se obtuvieron diferencias significativas entre las etapas de pre-contemplación y las etapas más avanzadas en todas las dimensiones de creencias de salud, excepto en la seriedad percibida p <.001. La autoeficacia y la motivación para la salud fueron diferentes entre las mujeres en la etapa de contemplación, mantenimiento y recaída. La identificación de las etapas de cambio para la adopción de mamografías puede ayudar a desarrollar e implementar estrategias de intervención más efectivas. Además, la autoeficacia percibida y la motivación para la salud pueden aumentar la adherencia a la mamografía como método de detección del cáncer de mama.

A clinico-pathological study of COVID-19 associated rhino-orbital-cerebral mucormycosis

Purpose: Known predisposing factors for mucormycosis are neutropenia and diabetes. Though COVID?19 is associated with hyperinflammatory response, a high surge in rhino?orbital?cerebral mucormycosis (ROCM) cases was observed during the second wave. The histopathological features reflect the background pathogenesis. This study analyzes the histopathological features and clinical presentation of COVID?19?associated ROCM. Methods: In this retrospective observational study, the clinical details of 89 proven ROCM patients treated during May–July 2021 were collected from the case records. Histopathological features were correlated with clinical staging groups and outcomes. The mean neutrophil?to?lymphocyte ratio (NLR) of clinical and outcome groups were compared. Results: The mean age was 54.71 ± 11.03 years, with male patients constituting a majority (78.7%). Uncontrolled diabetes mellitus was noted in 70.8% of patients, and 3.4% had normal range of blood sugar. The mean blood sugar was 298.08 ± 99.51 mg/dL. The mean duration of onset of symptoms of mucormycosis from the diagnosis of COVID?19 was 17.36 ± 7.392 (3–45) days. Poor outcome with disease progression or death occurred in 21.3% of patients. Clinical group II patients (44.9%) with ROCM stages 3c and above had poor outcomes (P = 0.005). Histopathological analysis showed minimal inflammation in 25.8%, neutrophil extracellular trap (NET) in 75.3%, and angio?invasion in 28.1% of patients. Minimal inflammation was associated with clinical group II (P = 0.004) and poor outcome (P = 0.001). Angio?invasion correlated with poor outcome (P = 0.007). Patients with severe clinical group and poor outcome had higher mean NLR with P = 0.017 and P = 0.007, respectively. Conclusion: Vision loss and cerebral involvement had poor outcomes. The histopathologic features such as inflammation and angio?invasion along with NLR aid as prognostic indicators in the management of ROCM. The role of NET in the pathogenesis of COVID?19?associated ROCM needs further studies